📋 Indications & Clinical Dosage
*Nausea and vomiting induced by chemotherapy:*
BY SLOW IV INJ OR INF: Adults: 5 mg by slow IV inj or INF shortly before chemotherapy followed by 1 cap each morning 1 hr before food for 5 days.
Children above 2 yr: 0.2 mg/kg by slow IV inj or INF shortly before chemotherapy up to a max daily dose of 5 mg. In children under 25 kg, repeat IV administration on day 2 up to day 5 depending on chemotherapy regimen, in children over 25 kg, 5 mg orally on day 2 up to day 6.
*Prevention of post-operative nausea and vomiting:*
BY SLOW IV INJ OR INF: Adults: 2 mg dose by slow IV or INF shortly before induction of an-aesthesia.
*Treatment of post-operative nausea and vomiting:*
BY SLOW IV INJ OR INF: Adults: One 2 mg dose by IV or INF within 2 hr of the end of an-aesthesia.
💊 Mode of Administration
Intermittent or via drip tubing in dextrose 5% or NaCI 0.9% or Ringers solution. Suggested concentrationfor infusion is 50 meg/ ml.
⚠️ Precautions & Warnings
Liver impairment, hypertension, cardiac rhythmor conduction disturbances.
🔄 Drug Interactions
Rifampicin and drugs affecting liver
enzymes or prolong QT interval.
⚠️ Adverse Reactions / Side Effects
Fatigue, dizziness, headache, constipation, GI disturbance, rarely collapse, syncope, bradycardia, cardiovascular arrest.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.