📋 Indications & Clinical Dosage
*Refractory oedema, hypertension associated with secondary hyperaldosteronism:*
Adults: 1-4 tab daily. Children: Not recommended.
⛔ Contraindications
Severe or progressive renal failure, precomatose states associated with liver cirrhosis, hyperkalaemia, Addisons disease.
⚠️ Precautions & Warnings
Prostatic hypertrophy, impaired micturition, hepatic or renal impairment, diabetes, gout.
🔄 Drug Interactions
K+ supplement, K-i4sparing diuretics, antihy-pertensives, ACE inhibitors, digitalis, lithium, aminoglycosides, cephalosporins, NSAIDs.
⚠️ Adverse Reactions / Side Effects
GI upset, rash, gout, blood dyscrasias, gy-naecomastia.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.