📋 Indications & Clinical Dosage
*immunization against gastro-enteritis caused by rotavirus:*
ORAL: Children 6-23 weeks: 1.5 ml for 2 at 4 weeks interval, first dose must be given between 6-14 weeks of age; course should becompleted before 24 weeks of age (preferably before16 weeks).
⛔ Contraindications
History or predisposition to intussusception, severe combined immunosuppression, history of chronic GI disease including congenital malformation of the GI tract, hypersensitivity
⚠️ Precautions & Warnings
Postpone vaccination in acute severe febrile ill-ness, diarrhoea and vomiting, immunosuppressed close contacts, vomiting (postponevaccination). The rotavirus vaccine virus is excreted in the stool andmay be transmitted to close contacts; care must be taken
⚠️ Adverse Reactions / Side Effects
Abdominal cramps, abdominal pain, diarrhoea, nausea, vomiting, fever, loss of appetite, irritability
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.