📋 Indications & Clinical Dosage
*Severe refractory psoriasis, Palmoplantarpustulosis, Congenitalichthyosis, Dariers disease:*
Adults: Initially 25-30 mg daily for 2 to 4 weeks, increase up to 75 mg daily, maintenance; 25-50 mg daily. Max duration of treatment 6 months. Children: Not recommended.
⛔ Contraindications
Renal or hepatic impairment, pregnancy; highly teratogenic, exclude pregnancy before the start of treatment, contraceptive measures must be taken before, during and for at least 2 years after withdrawal of treatment.
⚠️ Precautions & Warnings
Avoid blood donation for minimum 1 year after last dose, monitor liver function, serum lipids and bone changes, diabetes, avoid excessive UV exposure.
🔄 Drug Interactions
High dose vitamin A, methotrexate, tetracyclines, alcohol.
⚠️ Adverse Reactions / Side Effects
Severe headache, dry skin, sticky skin, dermatitis, erosion of mucosa, erythema, pruritus, palmer and plantar exfoliation, rhinitis, epistaxis, nail fragility, conjunctivitis, xerophthalmia, bullous eruptions, vulvovaginitis, drowsiness, sweating, gingivitis, alopecia, granulomatous lesions, GI upset, decreased night vision, hepatotoxicity, change in serum lipids, myalgia, arthralgia, hyperostosis and extraosseous calcification (long term therapy), photosensitivity, visual disturbance (withdraw immediately and refer for neurological examination)