📋 Indications & Clinical Dosage
*Treatment of advanced ovarian cancer and lung cancer (particularly the small cell type), head and neck cancers, bladder carcinoma, testicular carcinoma and when cisplatin cannot be administered:*
BY IV INF: Adult: Monotherapy: 360 mg/m2 IV on day 1, then every 4 weeks. Combination Therapy: 300 mg/m2IV on day 1, then every 4 weeks x 6 cycles. The dose of carboplatin is determined according to renal function rather than body surface area, dose adjustment based on platelet & neutrophil count (consult product literature).
💊 Mode of Administration
Administer as IV push or bolus over 15 min up to a continuous intravenous infusion over 24 hour, reconstitute powder to yield a final concentration of 10 mg/ml. May also be administered intraperitoneally. When administered as swquential infusions, tisane derivatives (docetaxel, paclitacel) should be administered before platinum derivatives to limit myelosuppression and to enhance efficacy. Do not use needles or IV administration sets containing aluminium parts that may come in contact with carboplation (aluminium can react causing precipitate formation and losss of potency)
⛔ Contraindications
Severe allergy to platinum components or mannitol.
⚠️ Precautions & Warnings
Peripheral blood conunts, renal and neurological function to be monitored closely.
⚠️ Adverse Reactions / Side Effects
Alopecia, bone-marrow suppression, extravasation, hyperuricaemia, myelosuppression, nausea, nephrotoxicity, neurotoxicity, oral mucositis, ototoxicity, thromboembolism, tumourlysis syndrome, vomiting
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Positive evidence of risk: Avoid
Lactation / Breastfeeding:
Contraindicated. Discontinue breast-feeding.
🧪 Compatibility & Storage Stability
Compatibility: Stable in D51/2 NS, D5NS, D5W, NS.
Stability & Storage: Store at 25C (77F). Protect from light. Use carboplation solutions within 8 hours of reconstitution or preparation when stored at room temperature (25C; 77F), excursions permitted from 15C -30C (59F-86F ). When stored in the original multi dose vial, the commercially available solution is stable for up to 14 days at room temperature even with multiple needle entries.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.