🩺 AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES 🏷️ Nitrothiazolyl-salicylamide prodrug
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Dry Susp 100mg/5ml 87004 60ml Rs.123.65 Rs.145.47
Dry Susp 100mg/5ml 87004 30ml Rs.63.37 Rs.74.55
Tab 500mg 98940 2x10 Rs.577.34 Rs.679.22

📋 Indications & Clinical Dosage

*Diarrhoea due to intestinal parasitic infections caused by cryptosporidium parvum and giardia lamblia:* Adults & Children above 12 yrs: 500 mg every 12 hr with food for 3 days. Children 1-3 yrs: 5 ml (100 mg) every 12 hr with food for 3 days; 4-11 yrs: 10 ml (200 mg) every 12 hr with food for 3 days.

⚠️ Precautions & Warnings

Hepatic or renal disease.

🔄 Drug Interactions

Highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g. warfarin).

⚠️ Adverse Reactions / Side Effects

Anorexia, flatulence, abdominal pain, headache, nausea, vomiting, constipation, dry mouth, thirst, asthenia, fever, pain, allergic reaction, pelvic pain, back pain, chills, fever, flu syndrome, dizziness, somnolence, insomnia, tremor, hypoesthesia, dysuria, amenorrhoea, metrorrhagia, kidney pain, oedema labia, increased SGPT, anaemia, leuko-cytosis,rash, pruritus, ear ache. Tachycardia, syncope, hypertension, myalgia, leg cramps, spontaneous bone fracture, discoloured urine

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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