📋 Indications & Clinical Dosage
*Oropharyngeal candidiasis:*
Adults: 2.5 ml four times daily.
Children 4 months to 2 yrs: 1.25ml four times daily. Apply directly with finger.Retain gel in mouth as long as possible.
*GI Tract Candidiasis:*
Adult: 5mg/kg four times daily, max 250mg.
Children above 4 months: same as adult, after all meals continue treatment for 7 days after healing.
⛔ Contraindications
Impaired swallowing reflex, first 5 - 6 months preterm-infant, hepatic impairment
⚠️ Precautions & Warnings
Avoid in acute porphyria, Pregnancy, Lactation.
🔄 Drug Interactions
Oral Anticoagulants, protease inhibitors, calcium channel blockers, mizolastine, midazolam, oral hypoglycaemics and drugs that prolong QT interval.
⚠️ Adverse Reactions / Side Effects
Mild GI upset, irritation and sensitivity reactions, Stevens - Johnson syndrome and toxic epidermal necrolysis.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.