📋 Indications & Clinical Dosage
*Nausea and vomiting, vertigo, IBS, dyspepsia, depression, anxiety, peptic ulcer and gastro-esophageal reflux disease:*
Adult:50 -200 mg
*Schizophrenia:*
Adults:200-400 mg twice daily, increase if necessary up to max 1.2 gm twice daily in patients with mainly positive symptoms or up to a total of 800 mg daily in patients with mainly negative symptoms, with neither predominating, are given usual dosage to 400-600 mg twice daily. Children above 14 yrs: 3-5 mg/kg daily.
*TOURETTEs SYNDROME:*
Adults & Children above 14 yrs: 200-400 mg twice daily.
⛔ Contraindications
Epilepsy, hyperprolactinaemia, mania, GI hemorrhage, comatose states, CNS depression, pheochromocytoma.
🔄 Drug Interactions
CNS depressants Alcohol, guanethidine, anticholinergic, antacids, NSAIDs.
⚠️ Adverse Reactions / Side Effects
Amenorrhea, gynacomastia, galactorrhoea, neuroleptic malignant syndrome, sedation, sleep disturbance, hypotension, agitation, dyskinesia, cardiovascular effects, hypotension.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.