📋 Indications & Clinical Dosage
*Treatment of corona virus COVID-19:*
BY IV INJ: Adult: An initial one-time dose of 200 mg; followed by 100 mg per day for 10 days.
Children: Less than 40 kg body weight: 5 mg/kg single loading dose followed by 2.5 mg/kg once daily for 10 days.
💊 Mode of Administration
Administered by IV infusion over 30-120 mins.
Reconstitute powder with 19 ml of SWFI, further dilute in 0.9 % NaCl infusion bag
⛔ Contraindications
Cardiac failure, severe renal or hepatic impairment
⚠️ Precautions & Warnings
Ensure effective contraception
during treatment. Ensure close monitoring of full blood count,
renal impairment and hepatic impairment; close monitoring required,
ensure adequate hydration during intravenous
administration.
🔄 Drug Interactions
Chloroquine phosphate, Hydroxychloroquine suphate
⚠️ Adverse Reactions / Side Effects
GI disturbance, alopecia, angina, anorexia, anxiety, diarrhoea, nausea, vomiting, increased liver enzyme levels that
may indicate possible liver damage.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Avoid, use only when no safer
alternative exists for a serious problem.
Lactation / Breastfeeding:
Contraindicated
🧪 Compatibility & Storage Stability
Compatibility: Stable in SWFI and NS
Stability & Storage: Stability of diluted solution at room temperature (25 C) for 4 hours
and at refrigeration temperature (4 C) is 24 hrs.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.