📋 Indications & Clinical Dosage
*Prevention and treatment of Potassium depletion especially during diuretic therapy:*
Adults: 20 mEq to 40 mEq daily in divided doses.
Children: Not recommended.
⛔ Contraindications
Serum plasma-potassium concentration above 5mmol/litre, severe renal impairment, acute dehydration, conditions predisposing to hyperkalaemia, gastric obstruction or ulceration, extensive tissue damage, metabolic acidosis.
⚠️ Precautions & Warnings
Renal impairment, cardiac disease; monitor serum electrolytes, history of peptic ulcer, elderly, pregnancy, lactation.
🔄 Drug Interactions
ACE inhibitors, angiotensin II receptor antagonists, cyclosporin, potassium sparing diuretics, tacrolimus.
⚠️ Adverse Reactions / Side Effects
GI upset, oesophageal or bowel obstruction, ulceration (discontinue).
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.