📋 Indications & Clinical Dosage
*Infections caused by gram-positive pathogens, anaerobic infections, chronic middle ear infection, colitis, impetigo, osteomyelitis, pneumonia:*
ORAL: Adults: 500 mg three or four times daily;
Children1-6 months: 1.25-2.5 ml three times daily; 6 months-2 yrs: 2.5-5 ml three times daily; 3-9 yrs: 2.5-5 ml four times daily; 10-12 yrs, 5-10 ml four times daily.
BY IM INJ OR IV INF: Adults: 600 mg by IM inj 12-24 hourly or IV INF 8-12 hourly.
Children 1 month & older: 10 mg/kg by IM inj 12-24 hourly; alternatively 10-20 mg/kg daily by IV INF in 2 or 3 divided doses at 8-12 hr intervals.
💊 Mode of Administration
For IV injection 1 gm lincomycin diluted in not less than 100 ml of appropriate solution and infused over a period of not less than one hour. Dilute 600 mg dose in at least 100 ml D5W, 010W, NS, dextrose 5% in NS, or other compatible diluent. Dilute higher doses in 100 ml of a compatible diluent for each gm being given.
⛔ Contraindications
Lincosamide sensitivity.
⚠️ Precautions & Warnings
Renal, hepatic, endocrine or metabolic disorders. Check liver function and blood regularly with pro-longed use.
🔄 Drug Interactions
Neuromuscular blocking drugs.
⚠️ Adverse Reactions / Side Effects
Abdominal discomfort, anaphylactoid reactions, antibiotic-associated colitis, diarrhoea (discontinue treatment), eosinophilia, exfoliative dermatitis, jaundice, leucopenia, nausea, oesophageal ulcers, oesophagitis, polyarthritis, pruritus, rash, Stevens-Johnson syndrome, taste disturbances, thrombocytopenia, toxic epidermal necrolysis, urticaria, vesiculobullous dermatitis, vomiting
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised, avoid
Lactation / Breastfeeding:
Contraindicated, avoid
🧪 Compatibility & Storage Stability
Compatibility: D5W 010W, D5NS, D1ONS. Ringers sol. In-compatible with novobiocin and kanamycin
Stability & Storage: Store at 20C-25C (68F-77F). Diluted lincomycin in an appropriate solution is physically compatible for 24 hours at room temperature unless otherwise indicated.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.