🩺 ANTIVIRALS FOR SYSTEMIC USE 🏷️ Nucleoside reverse transcriptase inhibitor
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 100 mg — 10 Rs.182.15 Rs.214.30
Tab 100 mg — 14 Rs.255.00 Rs.300.00

📋 Indications & Clinical Dosage

*HIV infection in combination with other antiretroviral drugs:* Adult: 150 mg every 12 hours, alternatively 300 mg once daily preferably without food. Children above 3 months: 4 mg/ kg twice daily, max 300 mg daily.

⚠️ Precautions & Warnings

Renal impairment; reduce dose, advanced liver disease due to Hepatitis B, pancreatitis.Recurrent hepatitis in patients with chronichepatitis B may occur on discontinuation of lamivudine.Initiate treatment under specialist supervision.

🔄 Drug Interactions

IV ganciclovir, foscarnet, co-trimoxazole.

⚠️ Adverse Reactions / Side Effects

Alopecia, muscle disorders, nasal symptoms, peripheral neuropathy, rhabdomyolysis, neutropenia, anaemia, thrombocytopenia, raised liver enzymes, serum amylase, headache, malaise, fatigue, GI disturbance, abdominal pain, insomnia, cough, musculoskeletal pain, pancreatitis,

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised, avoid

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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