📋 Indications & Clinical Dosage
*Hypertension:*
Adult: Initially 250 mg 2-3 times a day, dose should be increased gradually at intervals of at least 2 days; max. 3 g per day
Elderly: Initially 125 mg twice daily, dose should be increased gradually; max. 2 g per day
Children: Not recommended.
⛔ Contraindications
Acute porphyria, depression, phaeochromocytoma, liver disaese.
⚠️ Precautions & Warnings
History of depression, haemolytic anaemia, history of liver disorder, renal impairment, anaesthesia
🔄 Drug Interactions
Tricyclic, MAOIs, other anti-hypertensives, rau-yr/raffia alkaloids, hydralazine.
⚠️ Adverse Reactions / Side Effects
Amenorrhoea, arthralgia, asthenia, Bells palsy, bone-marrow depression, bradycardia, depression, dizziness, eosinophilia, exacerbation of angina, GI disturbances, gynaecomastia, haemolytic anaemia, hyperprolactinaemia, liver disorder, impotence, leucopenia, mild psychosis, myalgia, myocarditis, oedema. Pancreatitis, paraesthesia, pericarditis, postural hypotension, sialadenitis, thrombocytopenia, toxic epidermal necrolysis