HEPA-MERZ

🏢 BROOKES
🩺 BILE AND LIVER THERAPY 🏷️ Aminoacid 💊 BILE
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Granule 012143 5 Sachetx5 gm Rs.811.75 Rs.955.00
Inf 5 mg/10 ml 008633 1 Vial x 10 ml Rs.633.25 Rs.745.00
Syp 300 mg/5 ml 009031 120 ml Rs.425.00 Rs.500.00

📋 Indications & Clinical Dosage

*Hepatic encephalopathy, hepatitis, hepatic cirrhosis, jaundice, and a supportive therapy for tuberculosis:* BY INF: Adults: Acute hepatitis: 1-2 amp daily; Chronic hepatitis and hepatic cirrhosis: 2-4 amp daily; In pre-coma and coma: Up to 8 amp in 24 hr. INF rate max 5 gm/ /hr. BY IV INJ: Adults: 1 amp morning and 1 amp evening for 3-4 wk. ORAL: Granule: Adults: One sachet fully dissolved in water or juice once or twice daily. Syp: Adults: 2 tsp twice daily. Children: 1 tsp twice daily.

⚠️ Precautions & Warnings

Renal impairment, pregnancy. Monitor blood urea and serum creatinine regularly.

⚠️ Adverse Reactions / Side Effects

Transient nausea and vomiting.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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