📋 Indications & Clinical Dosage
*Preventing nausea and vomiting associated with emetogenic chemotherapy (adjunct to dexamethasone and a 5HT3-receptor antagonist):*
Adult: Initially 125 mg, dose to be taken 1 hour before chemotherapy, then 80 mg once daily for 2 days, consult product literature for dose of concomitant corticosteroid and 5HT3-antagonist
🔄 Drug Interactions
Pimozide, immunosuppressants, ergot alkaloids, fentanyl, alfentanil, etoposide, vinorelbine, antifungals, macrolides, protease inhibitors, rifampicin, phenytoin, carbamazepine, phenobarbital, oral anticoagulants, tolbutamide; any other substrate, inhibitor or inducer of CYP3A4 or substrate of CY92C9. lrinotecan, hormonal contraceptives, corticosteroids, benzodiazepines.
⚠️ Adverse Reactions / Side Effects
Headache, dizziness, anorexia, asthenia, constipation, diarrhoea, dyspepsia, hiccups, abdominal pain, anxiety, bradycardia, chills, colitis, confusion, conjunctivitis, dry mouth, duodenal ulcer, flushing, haematuria, hyperglycaemia, hyponatraemia, pruritus, rash, taste disturbance. Rare: Myalgia, neutropenia, oedema, palpitations, pharyngitis, polyuria, stomatitis, thirst, tinnitus, weight changes