📋 Indications & Clinical Dosage
*Treatment of acute exacerbation of chronic bronchitis:*
Adults: 320 mg once daily for 5 days.
*Treatment of community-acquired pneumonia, including pneumonia caused by multi drug resistant strains of S. pneumonia (MDRSP):*
Adults: 320 mg once daily for 7 days (for mild to moderate infections).
Children: Not recommended.
⚠️ Precautions & Warnings
Avoid use in patients with uncorrected hypokalaemia, hypomagnesaemia, bradycardia, acute myocardial ischaemia (may prolong QT interval) or at risk of seizures; discontinue in patients who experience significant CNS adverse effects. Tendon inflammation and/or rupture have been reported.
🔄 Drug Interactions
Other medications known to prolong the QT interval (including antiarrhythmics, cisapride, erythromycin, antipsychotics, and tricyclic antidepressants).
⚠️ Adverse Reactions / Side Effects
Diarrhoea, dizziness, headache, nausea, vomiting, abdominal pain, anorexia, anxiety, arthralgia, asthenia, blood disorders, confusion, depression, disturbances in taste, hearing, smell and vision, dyspepsia, eosinophilia, hallucinations, leucopenia, myalgia, rash, sleep disturbances, thrombocytopenia, tremor. Rare: Antibiotic-associated colitis, convulsions, dyspnea, hepatic dysfunction, hepatitis, hypotension, interstitial nephritis, jaundice, photosensitivity, psychoses, renal failure