📋 Indications & Clinical Dosage
*Lower urinary-tract infections:*
Adult: 400 mg twice daily for 7-10 days (for 3 days for uncomplicated infections in women).
*Chronic relapsing lower urinary-tract infections:*
Adult: 400 mg twice daily for up to 12 weeks; reduced to 400 mg once daily, if adequate suppression within first 4 weeks.
*Chronic prostatitis:*
Adult: 400 mg twice daily for 28 days.
Children: Not recommended.
⚠️ Precautions & Warnings
Avoid excessive alkalinity of urine and ensure adequate fluid intake (risk of crystalluria). Risk factor for QTinterval prolongation; caution advised in conditions such as: Acute myocardial infarction, bradycardia, congenital long QT syndrome, electrolyte disturbances, heart failure with reduced left ventricular ejection fraction, history of symptomatic arrhythmias, history of tendon disorder, epilepsy, history to CNS disorder, renal impairment, myasthenia gravis and elderly. Avoid prolonged exposure to UV. Discontinue treatment if psychiatric, neurological, or hypersensitivity reactions (including severe rash) occur.
🔄 Drug Interactions
Nitrofurantoin, theophylline, cyclosporin, oral anticoagulants, sucralfate, iron, zinc, antacids, probenecid, other quinolones, fenbufen, other NSAIDs.
⚠️ Adverse Reactions / Side Effects
Diarrhoea, dizziness, headache, nausea, vomiting, abdominal pain, anorexia, anxiety, arthralgia, asthenia, blood disorders, confusion, depression, disturbances in taste, hearing, smell and vision, dyspepsia, eosinophilia, hallucinations, leucopenia, myalgia, rash, sleep disturbances, thrombocytopenia, tremor.
Rare: antibiotic-associated colitis, convulsions, dyspnea, hepatic dysfunction, hepatitis, hypotension, interstitial nephritis, jaundice, photosensitivity, psychoses, renal failure, symptoms of peripheral neuropathy, tendon damage and inflammation, vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis