📋 Indications & Clinical Dosage
*Contraception:*
BY DEEP IM INJ: Females of childbearing potential: on the first day of a cycle then at intervals of 30 (plus minus 3 days), minimum 27, max 33 days, regardless of the cycle pattern, If the injection interval is more than 33 days, no adequate contraception cover will be available that time onwards.
⛔ Contraindications
Pregnancy, severe liver dysfunction, Dubin-Johnson syndrome, Rotor syndrome, liver tumour, thromboembolic processes in arteries or veins, sickle-cell anaemia, cancer of breast, endometrium, diabetes, disturbances of lipometabolism, history of herpes, otosclerosis with deterioration.
⚠️ Precautions & Warnings
Active trophoblastic disease (until return to normal of urine- and plasma gonadotrophin concentration),
arterial disease,functional ovarian cysts, history of jaundice in pregnancy, malabsorption syndromes, pastectopic pregnancy, sex-steroid dependent cancer, systemic lupus erythematosus with positive (or unknown) anti phospholipid antibodies, severe hepatic impairment, overdue menstrual bleeding, unprotected intercourse more than 72 hours previously in current menstrual cycle. Patients who still become pregnant should be monitored for ectopic pregnancy.
🔄 Drug Interactions
Barbiturates, phenylbutazone, hydantoins, ri-fampicin, ampicillin, oral antidiabetics, insulin.
⚠️ Adverse Reactions / Side Effects
Depression, headache, nausea, vomiting, breast discomfort, breast tenderness, changes in libido, disturbances of appetite, dizziness, fatigue, menstrual irregularities, skin disorders. Rare: Break-through bleeding (discontinue if heavy break-through bleeding) and amenorrhoea.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.