📋 Indications & Clinical Dosage
*Prophylaxis and treatment of malaria:*
Adults and Children above 6 months: 7-13 kg: Half tab, 13-24 kg: 1 tab, 24-36 kg: 2 tab, 36-75 kg: 3 tab, 75-100 kg: 4 tab, dose to be given once daily, 3 hrs before or 3 hrs after food, for 3 days. Max 2 courses in 12 months separated by at least 2 months.
⛔ Contraindications
History of arrhythmias, of clinical relevant bradycardia, and of congestive heart failure accompanied by reduced ventricular ejection fraction; family history of sudden death or of congenital QT interval prolongation.
⚠️ Precautions & Warnings
Impaired renal or hepatic functions, cardiac disease, electrolyte disturbances, concomitant use with other drugs known to cause QT-interval prolongation, monitor patients unable to take food (greater risk of recrudes-cence).
🔄 Drug Interactions
Inhibitors of CYP3A4, substrates of CYP2D6, grapefruit juice, class la and Ill antiarrhythmics, drugs prolonging QT interval, fluoroquinolones, azole antifungals, cisapride.
⚠️ Adverse Reactions / Side Effects
Abdominal pain, nausea, anorexia, diarrhoea, vomiting, headache, dizziness, asthenia, muscle weakness and pain, sleep disturbances, nausea, palpitation, prolonged QT interval, cough, paresthesia, arthralgia, myalgia, pruritus, rash.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.