📋 Indications & Clinical Dosage
*Acute myocardial infarction:*
Adult: 1 500 000 units, dose to be given over 60 minutes,within 12 hours of onset of symptom.
*Deep-vein thrombosis, Pulmonary embolism, Acute arterial thromboembolism, Central retinal venous or arterial thrombosis:*
Adult: 250 000 units, dose to be given over 30 minutes, then 100 000 units every 1 hour for up to 12-72 hours, according to condition with monitoring of clotting parameters (consult product literature)
*Acute pulmonary embolism:*
Adult: 3 million unit dose over 24 hr.
💊 Mode of Administration
For IV infusion, give continuously or intermittently;reconstitute with sodium chloride 0.9%, then dilutefurther with Glucose 5% or Sodium Chloride 0.9% after
reconstitution. Do not administer by IM injection, for IV or infra-coronary use only. Infusion pump is required. Use in-line filter >0.8 micron.
CANNULA OCCLUSION:
250000 units into cannula, clamp for 2
hours then aspirate contents and flushwith NS.
⛔ Contraindications
Allergy and cross-sensitivity; Contra-indicated if previous allergic reaction to streptokinase, recent streptokinasetherapy (5 days streptokinasepreviously), severe liver or kidney damage, recent haemorrhage,
haemorrhagic diathesis, severe hypotension, streptococcal infections, sub-acute bacterial endocarditis, recent surgery, bleeding tendencies.
⚠️ Precautions & Warnings
Obtain haemostatic status
of patient before starting therapy. Followup with anticoagulant therapy. Seeliterature.
🔄 Drug Interactions
Anticoagulants, drugs affecting platelet function.
⚠️ Adverse Reactions / Side Effects
Hypotension, arrhythmias, Febrile reactions. Rare; Guillain-Barrsyndrome, anaphylaxis
Haemorrhage.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Caution advised or effect undetermined
🧪 Compatibility & Storage Stability
Compatibility: Stable in D5W, NS.
Incompatible with dextrans
Stability & Storage: Intact vials should be stored at room temperature stability ofparenteral admixture at roomtemperature (25C) is 8 hours and atrefrigeration (4C) is 24 hours. Reconstituted solutions should berefrigerated.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.