📋 Indications & Clinical Dosage
*Relief of symptoms of vestibular disorders, such as vertigo, tinnitus, nausea, and vomiting in Menieres disease:*
Adult: 30 mg 3 times a day
Children 5-11 yrs: 15 mg 3 times a day; 12-17 yrs: 30 mg 3 times a day.
*Motion sickness:*
Adult: Initially 30 mg, 2 hours before travel, then 15 mg every 8 hours if required, dose to betaken during journey
Children 5-11 yrs: Initially 15 mg, 2 hours before travel, then 7.5 mg every 8 hours ifrequired, dose to be taken during journey; 12-17 yrs: Initially 30 mg, 2 hours before travel, then 15 mg every 8 hours ifrequired, dose to be taken during journey.
*Cerebral circulatory disorder:*
Adult: 25 mg every 8 hourly.
*Peripheral circulatory disorder:*
Adult: 50-75 mg every 8 hourly.
⛔ Contraindications
Porphyria.
⚠️ Precautions & Warnings
Parkinsons disease, hypotension, epilepsy, glaucoma, prostatic hypertrophy, pyloroduodenal obstruction, susceptibility to angle-closure glaucoma, urinary retention
🔄 Drug Interactions
Alcohol, CNS depressants, TCADs.
⚠️ Adverse Reactions / Side Effects
Drowsiness, anaphylaxis, blood disorders, bronchospasm, confusion, convulsions, depression, dizziness, extrapyramidal effects, hypersensitivity reactions, hypotension, lichenplanus, paradoxical stimulation, photosensitivity reactions, rashes, sleep disturbances, sweating, tremor, weight gain. Rare: Angioedema,angle-closure glaucoma, arrhythmias,liver dysfunction, lupus-like skin reactions, palpitation, paradoxical stimulation
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.