DOPRIL

*Hypertension:* Adult: Initially 5 mg Perindopril (as arginine) once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; max. 10 mg per day. Alternatively; Initially 4 mg Perindopril (as terbutylamine) once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; max. 8 mg per day. Elderly: Initially 2.5 mg Perindopril (as arginine) once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; max. 10 mg per day. Alternatively; initially 2 mg Perindopril (as terbutylamine)once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; max. 8 mg per day. *Hypertension, if used in addition to diuretic, or in cardiac decompensation or volume depletion:* Adult: Initially 2.5 mg Perindopril (as arginine) once daily for 1 month, dose tobe taken in the morning, then, adjusted according to response; max. 10 mg per day. Alternatively; initially 2 mg Perindopril (as terbutylamine)once daily for 1 month, dose to be taken in the morning, then, adjusted according to response; max. 8 mg per day. *Symptomatic heart failure (adjunct):* Adult: Initially 2.5 mg Perindopril (as arginine) once daily for 2 weeks, then increased if tolerated to 5 mg once daily, dose to be taken in the morning. Alternatively; Initially 2 mg Perindopril (as terbutylamine) once daily for at least 2 weeks, dose to be taken in the morning, then increased if tolerated to 4 mg once daily. *Prophylaxis of cardiac events following myocardial infarction or revascularisation in stable coronary artery disease:* Adult: Initially 5 mg Perindopril (as arginine) once daily for 2 weeks, then increased if tolerated to 10 mg once daily, dose to be taken in the morning. Alternatively; initially 4 mg Perindopril (as terbutylamine)once daily for 2 weeks, dose to be taken in the morning, then increased if tolerated to 8 mg once daily. Elderly: Initially 2.5 mg Perindopril (as arginine) once daily for 1 week, then increased if tolerated to 5 mg once daily for 1 week, then increased if tolerated to 10 mg once daily, dose to be taken in the morning. Alternatively; initially 2 mg Perindopril (as terbutylamine)once daily for 1 week, then increased if tolerated to 4 mg once daily for 1 week, then increased if tolerated to 8 mg once daily. Children: Not recommended.

Renal impairment, hepatic impairment; close monitoring is required, surgery/anaesthesia.

K+ sparing diuretics or K+ supplements, lithium, antidepressants.

Asthenia, mood disturbance, sleep disturbance, flushing, angioneurotic oedema, taste disturbance, nausea, abdominal pain, fatigue, headache, low haemoglobin, red cells and platelets counts, reversible increase in blood urea and creatinine, proteinuria, skin rashes