📋 Indications & Clinical Dosage
*Vertigo, nausea and vomiting, motion sickness:*
ORAL: Adults: 50-100 mg two or three times daily.
Children 1-6 yrs: 12.5-25mg; 7-12 yrs: 25-50 mg; two or three times daily.
BY IV OR IM INJ: Adults: 50-100 mg every 4 hr;
Children above 1 yr: IM 1.25 mg/kg 4 times daily, max 300 mg/day.
💊 Mode of Administration
For IV administration, each ml (50 mg) of solution must be diluted in 10 ml of NaCI 0.9%, injected over a period of 2 min.
⚠️ Precautions & Warnings
Patients with narrow angle glaucoma, obstructive disease of the GI or GU tract and in elderly males with possible prostatic hypertrophy, may have hypotensive actions.
🔄 Drug Interactions
Hypnotics, sedatives, tranquillizers, antianxiety drugs.
⚠️ Adverse Reactions / Side Effects
Tachycardia, palpitation, urticaria, dryness of mouth, nose and throat, drowsiness, restlessness, excitation, nervousness insomnia, euphoria, anorexia, nausea, vomiting, diarrhoea, atirstipation, hypotension, blurred vision, diplopia, vertigo tinnitus, urinary complications, auditory and visual hallucination, cholestatic jaundice(rare).
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Not recommended.
Lactation / Breastfeeding:
Caution advised
🧪 Compatibility & Storage Stability
Stability & Storage: Store at 20C-25C (68F-77F). Protect from light.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.