📋 Indications & Clinical Dosage
*Pain and inflammation associated with degenerative joint diseases such as osteoarthritis & related diseases:*
Adults: 1 cap twice daily. Children: Not recom-mended.
⛔ Contraindications
History of hypersensitivity to anthraquinone derivatives, pregnancy, kidney dysfunct
⚠️ Precautions & Warnings
Not to be taken concomitantly with laxatives. Reduce dose in patients with renal insufficiency. Monitor CBC, LFT and urine analysis every 6 months
🔄 Drug Interactions
Aluminium and magnesium containing antacids.
⚠️ Adverse Reactions / Side Effects
Accelerated intestinal transit time with diarrhoea, loose or soft stools within the 1st few days of therapy, urine discolouration, rash, pruritus, epigastric pain,
🤰 Pregnancy & Lactation Safety
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.