📋 Indications & Clinical Dosage
*Lower Respiratory Infection:*
BY IV INJ: Adults: 1-2 gm every 12 hr for 10 days. Children: 2 month- 16 yrs: 50 mg/kg every 12 hr. Max: 1gm.
*Urinary Tract Infection:*
BY IM OR IV INJ: Adults: 0.5-1 gm every 12 hr for 7-10 days. In severe infection: 2 gm every 12 hr for 10 days. Children: 2 month-16 yrs: 50 mg/kg IV every 12 hr. Max: 1 gm.
*Skin & soft-tissue Infection:*
BY IV INJ: Adults: 2 gm every 12 hr for 10 days. Children: 2 months -16 yrs: 50 mg/kg IV every 12 hr. Max: 1gm.
💊 Mode of Administration
Inject deep IM large muscle mass. Inject direct IV over 5 min. Infuse intermittent infusion over 30-60 min. IV Detail: pH 4-6. Reconstitute for IV using manufacturers guidelines. IM: Reconstitute 500 mg vial of drug with 1.3 ml of diluent, such as SWFI (or 1 gm vial with 2.4 ml of diluent). See drug to drug compatibility chart
⚠️ Adverse Reactions / Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, hallucinations, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis,
🧪 Compatibility & Storage Stability
Compatibility: Stable in D5LR, D5NS, D5W, D1OW, NS, bacteriostatic water, SWFI.
Y-site
Stability & Storage: In the dry state store at 2C-25C. Protect from light. Reconstituted solution may be stored up to 24 hours at controlled room temperature 20C -25C, or 7 days in a refrigerator, 2C-8C.