📋 Indications & Clinical Dosage
*Lower respiratory tract infections, complicated and uncomplicated UTI, intra-abdominal infections, bacterial septicaemia, polymicrobial infectionsand skin infections:*
BY SLOW IV INJ OR INF: Adults: 6 gm eight hourly. Children: Not recommended.
⚠️ Precautions & Warnings
Patients with low K+ reserves, renal failure, hepatic impairment; monitor renal and hepatic function dur-ing prolonged treatment, age above 50 years, serious underlying disease.
🔄 Drug Interactions
Probenecid, drugs affecting blood Coagulation and/or thrombocyte function.
⚠️ Adverse Reactions / Side Effects
Skin reactions, allergic reactions, superinfection, GI disturbances.Rare: Pseudomembranous Colitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Use only if essential
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.