📋 Indications & Clinical Dosage
*Non-neurological manifestations of type I and type III Gauchers disease (specialist use only):*
BY IV INF: Adult: Initially 60 units/kg every 2 weeks; maintenance dose to be adjusted according to response, 15 units/kg once every 2 weeks may improve haematological parameters and organomegaly.
💊 Mode of Administration
For IV infusion give intermittently in Sodium chloride 0.9%; initially reconstitute with water for injections (400 units in 10.2 ml) to give 40 units/ml solution; dilute requisite dose with infusion fluid to a final volume of 100–200 ml and give initial dose at a rate not exceeding 0.5 units/kg/minute, subsequent doses to be given at a rate not exceeding 1 unit/kg/minute; administer within 3 hours after reconstitution.
⚠️ Adverse Reactions / Side Effects
Abdominal cramps, angioedema, cough, dyspnoea, hypersensitivity, skin reactions, arthralgia, back pain, chest discomfort, chills, cyanosis, diarrhoea, dizziness, fatigue, fever, flushing, headache, hypotension, nausea, paraesthesia, tachycardia, vomiting