📋 Indications & Clinical Dosage
*Treatment of neuropsychological disorders of degenerative or vasculocere bralaetiology, cardiac stroke, head trauma, ischaemic heart disease, paralysis and adjunct in Parkinsons disease:*
BY IM OR SLOW IV INJ OR IV INF: Adults: 1 gm-2 gm daily IM or slow IV or IV INF (INF rate 40-60 drops/min), for 4 weeks.
ORAL: Adults: 600-2000 mg daily.
Children ab:ove 12 yrs 100 mg two to three times daily.
💊 Mode of Administration
By IM or IV (3-5 min) and IV drip (infusion rate of 40-60 drops/min). Direct IV should be administered very slowly to prevent episodes of hypotension.
⛔ Contraindications
Parasympathetic hypertonia, unconsciousness, brain surgery, pregnancy and lactation.
⚠️ Precautions & Warnings
Persistent intracranial haemorrhage, progressive disturbance of consciousness, reduce dose in hepatic and renal impairment
🔄 Drug Interactions
Levodopa.
⚠️ Adverse Reactions / Side Effects
Hypotension, insomnia,, excitement
🧪 Compatibility & Storage Stability
Compatibility: Hypertonic glucose solution and all IV isotonicsolns.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.