📋 Indications & Clinical Dosage
*Primary carnitine deficiency due to inborn errors of Metabolism:*
Adult: Up to 200 mg/kg daily in 2-4 divided doses, max. 3 g per day
BY SLOW IV INJECTION: Adult: Up to 100 mg/kg daily in 2-4 divided doses, to be administered over 2-3 min
*Secondary carnitine deficiency in haemodialysis patients:*
BY SLOW IV INJ: Adult: Initially 20 mg/kg, to be administered over 2-3 min, after each dialysis session, dosage adjusted according to plasma-carnitine concentration, then (oral) maintenance 1 gm daily
⚠️ Precautions & Warnings
Diabetes mellitus, Accumulation of metabolites may occur with chronic oral administration in severe renal impairment. Monitoring of free and acyl carnitine in blood and urine recommended.
⚠️ Adverse Reactions / Side Effects
Abdominal cramps, diarrhoea, nausea, vomiting, abnormal skin odour, allergic reactions
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
No evidence of harm
Lactation / Breastfeeding:
No evidence of harm
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.