🩺 CARDIAC THERAPY 🏷️ Vasodilator/Potassium-channel openers
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 2.5mg 117399 3x10 Rs.2958.00 Rs.3480.00

📋 Indications & Clinical Dosage

*Severe hypertension, in addition to a diuretic and a beta- blocker:* Adult: Initially 5 mg daily in 1–2 divided doses, then increased in steps of 5–10 mg, increased at intervals of at least 3 days; max. 100 mg per day. Elderly: Initially 2.5 mg daily in 1–2 divided doses, then increased in steps of 5–10 mg, increased at intervals of at least 3 days; max. 100 mg per day.

⛔ Contraindications

Phaeochromocytoma

⚠️ Precautions & Warnings

Acute porphyrias, after myocardial infarction (until stabilised), angina, renal impairment

🔄 Drug Interactions

Guanethidine (avoid)

⚠️ Adverse Reactions / Side Effects

GI disorder, fluid retention, oedema, sodium retention, hair changes, pericardial disorders, pericarditis, tachycardia, breast tenderness, pleural effusion, weight increased. Rare: Leucopenia, skin reactions, Stevens- Johnson syndrome, thrombocytopenia, Angina pectoris

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Aviod
Lactation / Breastfeeding:
No harm

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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