🩺 ANTIMIGRAINE PREPARATIONS 🏷️ Ergot alkaloid/Xanthine
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 1/100 mg 000511 10 Rs.127 Rs.150

📋 Indications & Clinical Dosage

*Treatment of acute migraine and migraine variants:* Adults: 1 or 2 tab at onset of attack; max 4 tab daily, 10 tabs in any one wk. Children: Not recommended.

⛔ Contraindications

Acute porphyrias, coronary, heart disease, hyperthyroidism, uncontrolled or severe hypertension, obliterative vascular disease, peripheral vascular disease, Raynauds syndrome, sepsis, temporal arteritis

⚠️ Precautions & Warnings

Anaemia, cardiac disease, dependence, elderly; risk of peripheral vasospasm

🔄 Drug Interactions

Erythromycin, beta-blockers.

⚠️ Adverse Reactions / Side Effects

Abdominal pain, dizziness, nausea, vomiting, cyanosis, diarrhoea, hypoaesthesia, pain and weakness in extremities, paraesthesia, peripheral vasoconstriction, anxiety, arthralgia, blood disorders, blurred vision, cerebral ischaemia, confusion, constipation, depression, drowsiness, dry mouth.. Rare Arrhythmias, bradycardia, dyspnea, ergotism, increased blood pressure, intestinal ischaemia, myalgia, rash, tachycardia, urticaria, hallucinations, seizures, sleep disturbances, thrombosis, tremor, urinary retention

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Contraindicated
Lactation / Breastfeeding:
Contraindicated

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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