📋 Indications & Clinical Dosage
*Improvement of ulcers, pain and feeling of coldness associated with chronic arterial occlusion:*
Adults: 40 mcg three times daily.
*Primary Pulmonary hypertension:*
Adults: 1 mcg/kg/day up to 20 mcg three times daily. Gradually increase dose if needed up to max 180 mcg in three or four divided doses. Reduce dose to 0.5mcg/kg/day or 20-40 mcg daily in 2-3 divided doses if adverse reaction occur, or discontinue if needed.
Children: Not recommended.
⛔ Contraindications
Patients with haemorrhage.
⚠️ Precautions & Warnings
It may enhance bleeding tendency, patients on anticoagulants, antiplatelet, or fibrinolytic agents, menstruating women, liver and renal impairment.
🔄 Drug Interactions
Anticoagulants, antiplatelet or fibrinolytic agents or any product that intensifies bleeding tendency.
⚠️ Adverse Reactions / Side Effects
Dizziness, headache, flushing, nausea, diarrhea, increased liver enzyme, bilirubin, and triglyceride concentrations, enhanced bleeding tendency
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Caution advised, not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.