📋 Indications & Clinical Dosage
*Asthma, conditions associated with reversible airways obstruction:*
Adult (patients who have previously tolerated beta2-agonists): 20 mg once daily, dose to be taken at bedtime;
Adult: (patients who have not previously tolerated beta2-agonists): Initially 10 mg once daily for 1-2 weeks, then increased if necessary to 20 mg once daily, dose to betaken at bedtime.
⛔ Contraindications
Severe hepatic impairment.
⚠️ Precautions & Warnings
Renal impairment; reduce dose, cardiovascular disorder, diabetes, myocardial insufficiency, thyrotoxicosis. Monitor serum potassium levels in severe asthma.
🔄 Drug Interactions
Suxamethonium, beta blockers.
⚠️ Adverse Reactions / Side Effects
Tonic muscle cramps, headache, hypokalaemia, tremor, palpitations
🤰 Pregnancy & Lactation Safety
Lactation / Breastfeeding:
Avoid
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.