📋 Indications & Clinical Dosage
*Diarrhoea:*
Adults: Initially 4 tab, then 2 tab six hourly until controlled.
Children below 5 yr: not recommended; 5-8 yr:1 tab three times daily; 9-12 yr:1 tab four times daily; 13-16 yr:2 tab three times daily.
⛔ Contraindications
Intestinal obstruction, acute ulcerative colitis, Pseudomembranous colitis, Crohns disease, hepatic dysfunction.
⚠️ Precautions & Warnings
Dehydration or electrolyte imbalance should be treated before initiating therapy, young children, inflammatory bowel disease, hepatic impairment.
🔄 Drug Interactions
MAOIs, CNS depressants.
⚠️ Adverse Reactions / Side Effects
Pancreatitis, paralytic ileus, hyperglycemia, hemorrhagic colitis, toxic megacolon, CNS disturbances, allergic reactions, pseudomembranous colitis, anaphylactoid reaction.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Not recommended.
Lactation / Breastfeeding:
Caution advised.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.