📋 Indications & Clinical Dosage
*Allergic rhinitis, Bronchial asthma:*
Adult: 1 mg twice daily with food, increased if necessary to 2 mg twice daily
Children 3-17 yrs: 1 mg twice daily with food.
*Allergic rhinitis in readily sedated patients:*
Adult: Initially 0.5-1 mg once daily, dose to be taken at night.
⚠️ Precautions & Warnings
CNS disorder, cardiac disorder, severe renal and hepatic impairment, history of epilepsy. Withdraw over 2-4 weeks in asthma patients.
🔄 Drug Interactions
Alcohol, CNS depressants, oral hypoglycaemics, antihistamines.
⚠️ Adverse Reactions / Side Effects
GI distress, headache, nausea, anxiety, restlessness, insomnia, drowsiness, impaired reactions, dry mouth, dizziness.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised or avoid
Lactation / Breastfeeding:
Caution advised or avoid
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.