🩺 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, SYSTEMIC 🏷️ Leukotriene receptor antagonists
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 10 mg 035778 14 Rs.263.50 Rs.310.00
Tab 4 mg 035776 14 Rs.161.50 Rs.190.00
Tab Chewable 5 mg 035777 14L 204.00 — Rs.240.00

📋 Indications & Clinical Dosage

*Prophylaxis of asthma:* Adult & Children above 15 yrs: 10 mg once daily in the evening. Children 6 months-5 yrs: 4 mg once daily in the evening; 6-14 yrs: 5 mg once daily inthe evening. *Symptomatic relief of seasonal allergic rhinitis in patients with asthma:* Adult & Children above 15 yrs: 10 mg once daily in the evening.

⚠️ Precautions & Warnings

Do not substitute abruptly for inhaled or oral steroid therapy, not for use for relief of acute symptoms. Discontinue if symptoms of Churg-Strauss syndrome appear. Phenyl ketonuria with chewable tablet (contain aspartame).

🔄 Drug Interactions

Phenobarbital, phenytoin, rifampicin.

⚠️ Adverse Reactions / Side Effects

Abdominal pain, aggressive behavior, agitation, anxiety, headache, hyperkinesia, thirst, depression, dizziness, drowsiness, dry mouth, epistaxis, irritability, malaise, muscle cramps, hyperactivity, restlessness, sleep disturbances, palpitation, tremor. Rare: Anaphylaxis, angioedema, seizure, elevated ALT/AST, Churg-Strauss syndrome (Discontinue)

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Not known to be harmful
Lactation / Breastfeeding:
Caution advised

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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