📋 Indications & Clinical Dosage
*Prophylaxis and treatment of deficiencies of vit C. Scurvy:*
ORAL OR BY IM OR SLOW IV INJ: Adults: 500 mg-1 gm daily in 1-2 divided doses for at least 2 week.
Children1 month-4 yrs: 125-250 mg daily in 1-2 divided doses; 4-12 yrs: 250-500 mg daily in 1-2 divided doses; 12-18 yrs: 500 mg-1 gm daily in 1-2 di-vided doses.
*Adjunct in treatment of wounds and infections:*
Adult: 4-12 gm daily in 3-4 divided does. Children above 1 yr: 500 mg every 6-8 hr
*Dietary supplement:*
Adult: 50-200 mg daily. Children: 35-100 mg daily.
*Adjunct to desferrioxamine therapy to enhance excretion of iron:*
Adult & Children1 mth-18 yrs: 100-200 mg daily 1 hr before food, after one month of therapy
⛔ Contraindications
Hyperoxaluria
⚠️ Precautions & Warnings
Diabetics, patients prone to renal calculi.
🔄 Drug Interactions
Iron preps, oral contraceptives, fluphenazine, warfarin.
⚠️ Adverse Reactions / Side Effects
Kidney oxalate stones, hyperoxaluria, diarrhoea, GI disturbance, dizziness, faintness, fatigue, flank pain, headache.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised
🧪 Compatibility & Storage Stability
Stability & Storage: Dispensing vial: Store in carton until time of use. Store below 23C (73F). Protect from light
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.