ARIXA

*Prophylaxis of venous thromboembolism following knee or hip replacement surgery:* Adult: 10 mg once daily, 6-10 hours after surgery, for 2 weeks. *Initial treatment of deep-vein thrombosis and pulmonary embolism:* Adult: Initially 15 mg twice daily for 21 days, to be taken with food *Continued treatment of deep-vein Thrombosis and Pulmonary Embolism:* Adult: 20 mg once daily, to be taken with food *Prophylaxis of stroke and systemic embolism in patients with non-valvular atrial fibrillation and with at least one of the following risk factors: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age 75 years, or diabetes mellitus:* Adult: 20 mg once daily, to be taken with food *Prophylaxis of atherothrombotic events following an acute coronary syndrome with elevated cardiac biomarkers:* Adult: 2.5 mg twice daily(in combination with aspirin alone or aspirin and clopidogrel)for 1 yr.

Creatinine clearance <15 ml/min, active bleeding, in acute coronary syndrome, previous or transient stroke, malignant neoplasms, oesophageal varices, recent brain, ophthalmic, orspinesurgery, GI ulcer, intracranial haemorrhage, significant risk of major bleeding, vascular aneurysm

Severe renal impairment, Cirrhotic patients with moderate hepatic Impairment, severe hypertension, Spinalor epidural anaesthesia, lumbar puncture

Azole antifungals, protease inhibitors, NSAIDs, strongCYP3A4 inducers, anticoagulants, antiplatelets.

Abdominal pain, constipation, diarrhoea, dizziness, dyspepsia, haemorrhage, hypotension, nausea, vomiting, pain in extremities, pruritus, renal impairment, angioedema, dry mouth, malaise, syncope, tachycardia, thrombocythaemia. Rare: Jaundice, oedema