🩺 ANTIDEPRESSANTS 🏷️ SSR1s/Thienobenzodiazepine
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Cap 6/25 mg — 10 Rs.152.15 Rs.179.00

📋 Indications & Clinical Dosage

*Treatment resistant depression, Depression associated with Bipolar 1 disorder:* Adult: Initially25 mg/6 mg per day in evening then increase gradually if needed; max 75 mg/18 mg per day.

⚠️ Precautions & Warnings

Hepatic and renal disease, cardiac disease, allergy, breast cancer, intestinal problems, low blood pressure, neuroleptic malignant syndrome, narrow-angle glaucoma, prostate problem, seizures, stomach problems, dehydration, dementia, stroke, dehydration, low white blood cell.

⚠️ Adverse Reactions / Side Effects

Agitation, anxiety, arthralgia, blood disorders, confusion, convulsions, dizziness, drowsiness, dry mouth, fatigue, headache, increased appetite, insomnia, myalgia, oedema, postural hypotension, tremor, weight changes, hallucinations, mania, movement disorders, syncope, dysarthria, hypersalivation, hyponatraemia, inappropriate secretion of antidiuretic hormone, sedation during initial treatment Rare: Aggression, myoclonus, pancreatitis, angle-closure glaucoma, Stevens-Johnson syndrome, suicidal behavior, toxic epidermal necrolysis

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Avoid unless potential benefit outweighs risk
Lactation / Breastfeeding:
Contraindicated, avoid

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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