🩺 ACE INHIBITOR 🏷️ ACE inhibitor/Calcium antagonist
👨‍⚕️ Clinically Reviewed by: PakistaniBano Medical Editorial Board (Pharm.D Panel)
📅 Reviewed: November 2026 • 🔍 Authority: DRAP / WHO ATC
📦 Formulations, Pack Sizes & Retail Prices Currency: Rs.
Dosage Form Reg. No Pack Size Trade Price (TP) Maximum Retail Price (MRP)
Tab 5/4 mg — 10 Rs.140.25 Rs.165.00
Tab 10/4 mg — 10 Rs.140.25 Rs.165.00
Tab 5/8 mg — 10 Rs.187.00 Rs.220.00
Tab 10/8 mg — 10 Rs.178.5 Rs.210.00

📋 Indications & Clinical Dosage

*Hypertension in patients inadequately controlled by individual component in the same proportion:* Adults: 1 tab once daily according to requirement. Children: Not recommended.

⛔ Contraindications

Cardiogenic shock, aortic stenosis, unstable angina, hypersensitivity to dihydropyridines

⚠️ Precautions & Warnings

Within one month of MI, impaired hepatic function, renal impairment, surgery/anaesthesia, hyerptensive crisis.

🔄 Drug Interactions

K+ sparing diuretics or K+ supplements, lithium, antidepressants.

⚠️ Adverse Reactions / Side Effects

Headache, oedema, fatigue, nausea, GI upset, flushing and dizziness, rash, gingival hyperplasia, mood changes, dry mouth, palpitations, dyspnoea, muscle cramps, asthenia, Rarely, alopecia, pruritus, angioedema, somnolence, myalgia, arthralgia, pe-ripheral neuropathy, pancreatitis, increased micturition, hyperglycaemia, impotence, sweating, syncope, thrombocytopenia, vasculitis, visual dis-turbances, asthenia, mild cough, decreases in haemoglobin, red cells and platelets counts, reversible increase in blood urea and creatinine, proteinuria

🤰 Pregnancy & Lactation Safety

Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.

📚 Official Regulatory & Clinical References

  • Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
  • World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
  • Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.

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