📋 Indications & Clinical Dosage
*Vitamin B6 deficiency:*
ORAL: Adults: 20-50 mg 3 times daily for 3 weeks.
BY IM OR IV INJ: Adult: 10-20 mg daily for 3 weeks.
*Isoniazid or penicillamine or hydralazine or cycloserine induced neuropathy:*
ORAL: Adults: 10-20mg daily increase up to 50 mg 3 times daily.
BY IM OR IV INJ: Adult: 100 mg daily for 3 weeks followed by a 30 mg maintenance dose daily.
*Idiopathic sideroblastic anaemia:*
Adults: 100-400 mg daily in divided doses.
Children: Not recommended.
⛔ Contraindications
Hypersensitivity
⚠️ Precautions & Warnings
Dependence and withdrawal may occur with daily doses of 200 mg or more.
🔄 Drug Interactions
Levodopa, phenobarbital, phenytoin.
⚠️ Adverse Reactions / Side Effects
Sensory neuropathy reported with high doses given for extended periods.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.