📋 Indications & Clinical Dosage
*Infection of respiratory tract, urinary tract, skin & soft tissue, bone & joint and intra-abdominal infections, peritonitis, cholecystitis, septicaemia, meningitis:*
BY IV INJ: Adults: 2-4 gm a day in equally divided doses every 12 hr, may be increased up to max 8 gm a day (equivalent to cefoperazone 4 gm a day) in severe infections.
Children: 40-80 mg/kg/day in 2-4 equally divided doses, may be increased up to max 180 mg/kg/day in severe infections. Newborn infants to 1 week: 40-80 mg/kg/day every 12 hr. Max sulbactam dose in children 80 mg/kg/day. For cefoperazone dose higher than 80 mg/kg/day, given cefoperazone separately.
⛔ Contraindications
History of allergies to penicillins, cephalosporins or sulbactam.
🔄 Drug Interactions
Physical incompatibility with aminoglycoside, doxycycline, meclofenoxate, ajmaline, hydroxyzine, pro-cainamide, aminophylline, prochlorperazine, cytochrome C, pentazocine, aprotinin.
⚠️ Adverse Reactions / Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised
Lactation / Breastfeeding:
Caution advised
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.