📋 Indications & Clinical Dosage
*Treatment of gastric ulcer and duodenal ulcer:*
Adult: 20 mg once daily for up to 8 weeks for gastric ulcer and up to 6 weeks for duodenal ulcer.
*Treatment of reflux esophagitis:*
Adult: 20 mg once daily for up to 4 weeks, may be extended for up to 8 weeks if the efficacy is inadequate. Maintenance dose: 10 mg or 20 mg once daily.
*Prevention of recurrent gastric or duodenal ulcer associated with low-dose aspirin:*
Adult: 10 mg once daily.
*Prevention of recurrent gastric or duodenal ulcer associated with non-steroidal anti-inflammatory drug:*
Adult: 10 mg once daily.
*Adjunct therapy to Helicobacter pylori eradication:*
Adult: 20 mg of vonoprazan, as an adjunct to 750 mg of amoxicillin hydrate, and 200 mg of clarithromycin at the same time twice daily for 7 days, the dose of clarithromycin may be increased up to 400 mg twice daily. As alternative treatment: 20 mg of vonoprazan, 750 mg of amoxicillin hydrate, and 250 mg of metronidazole.
⛔ Contraindications
Severe hepatic impairment
⚠️ Precautions & Warnings
Mild to moderate hepatic impairment, elevation of intragastric pH, renal Impairment, metabolic disorder, elderly.
🔄 Drug Interactions
Drugs depend on gastric pH for absorption (atazanavir, rilpivirine, nelfinavir), Itraconazole, digoxin, tyrosine kinase inhibitors
⚠️ Adverse Reactions / Side Effects
Constipation, diarrhea, enlarged feeling of abdomen, nausea, rash and edema.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Caution advised, avoid
Lactation / Breastfeeding:
Caution advised, avoid
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.