📋 Indications & Clinical Dosage
*Prophylaxis against NSAIDs induced gastric ulceration in rheumatoid arthritis, osteoarthrosis:*
Adults: 1 tab of 50 mg two-three times daily or 1 tab of 75 mg two times daily. Children: Not recommended.
⛔ Contraindications
Active peptic ulcer, aspirin/anti-inflammatory induced allergy, women planning pregnancy
⚠️ Precautions & Warnings
History of GIlesions, renal, hepatic or cardiac impair-ment, cerebrovascular coronary or peripheral disease, premenopausal women should use effective contraception. Monitor patients on long-term treatment.
🔄 Drug Interactions
Salicylates, methotrexate, lithium, digoxin, diuretics, cyclosporin, anticoagulants, oral hypoglycaemics, quinolones, NSAIDs, steroids.
⚠️ Adverse Reactions / Side Effects
Menorrhagia, intermenstrual bleeding, skin reactions, headache, dizziness, oedema, depression, diarrhoea, drowsiness, fluid retention, GI disturbances, haematuria, headache, hearing disturbances, hypersensitivity reactions, insomnia, nausea, nervousness, photosensitivity, raised blood pressure, rashes
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy
Lactation / Breastfeeding:
Contraindicated or not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.