📋 Indications & Clinical Dosage
*Benign gastric ulceration, Benign duodenal ulceration, NSAID-associated ulceration:*
Adult: 800 mcg daily in 2-4 divided doses for at least 4 weeks, may be continued for up to 8 weeks if required, dose to be taken with breakfast (or main meals) and at bedtime.
*Prophylaxis of NSAID-induced gastric ulcer, Prophylaxis of duodenal ulcer:*
Adult: 200 mcg 4 times a day, reduced if not tolerated to 200 mcg 2-3 times a day.
Children: Not recommended.
⛔ Contraindications
Women of childbearing age.
⚠️ Precautions & Warnings
Conditions where hypotension might precipitate severe complications (e.g. cerebrovascular disease, cardiovascular disease).
🔄 Drug Interactions
Antacids.
⚠️ Adverse Reactions / Side Effects
Most common side effect is diarrhoea that may get severe and can be reduced by giving single doses not exceeding 200 mcg and by avoiding magnesium-containing antacids. Flatulence, dizziness, headache, abdominal pain, skin rashes, cramps, hypotension, nausea, vomiting, dysmenorrhea, hypermenorrhea, spoting.
🤰 Pregnancy & Lactation Safety
Pregnancy Risk:
Contraindicated in pregnancy.
Lactation / Breastfeeding:
Not recommended.
📚 Official Regulatory & Clinical References
- Drug Regulatory Authority of Pakistan (DRAP): Drug Registration, S.R.O. Price Gazettes & National Essential Medicines List (NEML).
- World Health Organization (WHO): Collaborating Centre for Drug Statistics Methodology (ATC/DDD Index).
- Formulary Standards: British National Formulary (BNF) & Pakistan National Formulary (PNF) guidelines.